Membrane-anchored PrPSc is the trigger for prion synaptotoxicity.
The mechanism by which prions composed of PrPSc cause the neuropathological aberrations characteristic of prion diseases remains elusive. Previous studies have defined a synaptotoxic signaling pathway in which extracellular PrPSc stimulates NMDA receptor-mediated Ca2+ influx, activation of p38 MAPK,...
में बचाया:
| मुख्य लेखकों: | , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Public Library of Science (PLoS)
2026-01-01
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| श्रृंखला: | PLoS Pathogens |
| ऑनलाइन पहुंच: | https://doi.org/10.1371/journal.ppat.1013911 |
| टैग: |
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