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APOE2 is associated with longevity independent of Alzheimer’s disease

Although the ε2 allele of apolipoprotein E (APOE2) benefits longevity, its mechanism is not understood. The protective effects of the APOE2 on Alzheimer’s disease (AD) risk, particularly through their effects on amyloid or tau accumulation, may confound APOE2 effects on longevity. Herein, we showed...

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Principais autores: Mitsuru Shinohara, Takahisa Kanekiyo, Masaya Tachibana, Aishe Kurti, Motoko Shinohara, Yuan Fu, Jing Zhao, Xianlin Han, Patrick M Sullivan, G William Rebeck, John D Fryer, Michael G Heckman, Guojun Bu
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2020-10-01
Colecção:eLife
Assuntos:
APOE
longevity
Alzheimer's disease
Acesso em linha:https://elifesciences.org/articles/62199
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