Efficient and flexible Integration of variant characteristics in rare variant association studies using integrated nested Laplace approximation.
Rare variants are thought to play an important role in the etiology of complex diseases and may explain a significant fraction of the missing heritability in genetic disease studies. Next-generation sequencing facilitates the association of rare variants in coding or regulatory regions with complex...
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| Glavni autori: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science (PLoS)
2021-02-01
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| Serija: | PLoS Computational Biology |
| Online pristup: | https://doi.org/10.1371/journal.pcbi.1007784 |
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