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Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence

Magainin 2 (<b>Mag2</b>), which was isolated from the skin of the African clawed frog, is a representative antimicrobial peptide (AMP) that exerts antimicrobial activity via microbial membrane disruption. It has been reported that the helicity and amphipathicity of <b>Mag2</b> play important roles i...

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Main Authors: Motoharu Hirano, Chihiro Saito, Hidetomo Yokoo, Chihiro Goto, Ryuji Kawano, Takashi Misawa, Yosuke Demizu
Format: Artigo
Language:Inglês
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
antimicrobial peptides
magainin 2
stapled peptide
helical structure
amphipathicity
Online Access:https://www.mdpi.com/1420-3049/26/2/444
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