Pralatrexate represses the resistance of HCC cells to molecular targeted agents via the miRNA-34a/Notch pathway

Abstract Metabolism-related pathways are important targets for intervention in the treatment of hepatocellular carcinoma (HCC), but few studies have reported on the combination of inhibitors of folate metabolism-related enzymes and molecularly targeted drugs for HCC. The results of the present work...

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Autores principales:	Yang Jin, Qiming Liu, Baisheng Sun, Xiaokang Li, Jiahao Wu, Zhiyuan Lin, Yan Ma, Haijiang Jia
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Springer 2024-11-01
Colección:	Discover Oncology
Materias:	Dihydrofolate reductase Hepatocellular carcinoma Promoter methylation miRNA-34a Notch pathway Drug resistance
Acceso en línea:	https://doi.org/10.1007/s12672-024-01572-2
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