A Purification Strategy Utilizing Hydrophobic Interaction Chromatography to Obtain Homogeneous Species from a Site-Specific Antibody Drug Conjugate Produced by AJICAP™ First Generation

In recent years, site-specific antibody drug conjugates (ADC)s have been in great demand because they have an expanded therapeutic index compared with conventional ADCs. AJICAP™ technology is a chemical conjugation platform to obtain site-specific ADCs through the use of a class of Fc-affinity compo...

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Principais autores:	Yutaka Matsuda, Monica Leung, Tatsuya Okuzumi, Brian Mendelsohn
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-05-01
coleção:	Antibodies
Assuntos:	antibody drug conjugate site-specific conjugation hydrophobic interaction chromatography (HIC) purification AJICAP™
Acesso em linha:	https://www.mdpi.com/2073-4468/9/2/16
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