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An innovative diagnostic technology for the codon mutation C580Y in kelch13 of Plasmodium falciparum with MinION nanopore sequencer

Abstract Background The recent spread of artemisinin (ART)-resistant Plasmodium falciparum represents an emerging global threat to public health. In Southeast Asia, the C580Y mutation of kelch13 (k13) is the dominant mutation of ART-resistant P. falciparum. Therefore, a simple method for the detecti...

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Principais autores: Kazuo Imai, Norihito Tarumoto, Lucky Ronald Runtuwene, Jun Sakai, Kyoko Hayashida, Yuki Eshita, Ryuichiro Maeda, Josef Tuda, Hideaki Ohno, Takashi Murakami, Shigefumi Maesaki, Yutaka Suzuki, Junya Yamagishi, Takuya Maeda
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-05-01
Serier:Malaria Journal
Fag:
Malaria
Plasmodium falciparum
Artemisinin resistance
LAMP
Nanopore sequencer
MinION™
Online adgang:http://link.springer.com/article/10.1186/s12936-018-2362-x
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