Discovery of pyrimidine-tethered benzothiazole derivatives as novel anti-tubercular agents towards multi- and extensively drug resistant Mycobacterium tuberculosis

In this study, new benzothiazole–pyrimidine hybrids (5a–c, 6, 7a–f, and 8–15) were designed and synthesised. Two different functionalities on the pyrimidine moiety of lead compound 4 were subjected to a variety of chemical changes with the goal of creating various functionalities and cyclisation to...

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Autores principales:	Loah R. Hemeda, Mahmoud A. El Hassab, Mohamed A. Abdelgawad, Eman F. Khaleel, Marwa M. Abdel-Aziz, Faizah A. Binjubair, Sara T. Al-Rashood, Wagdy M. Eldehna, Mohamed K. El-Ashrey
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis Group 2023-12-01
Colección:	Journal of Enzyme Inhibition and Medicinal Chemistry
Materias:	Benzothiazole DprE1 anti-mycobacterial activity molecular docking screening
Acceso en línea:	https://www.tandfonline.com/doi/10.1080/14756366.2023.2250575
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