Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties

With the aim of increasing the structural diversity on the early antimalarial drug plasmodione, an efficient and versatile procedure to prepare a series of biaryl- and N-arylalkylamines as plasmodione analogues is described. Using the naturally occurring and commercially available menadione as start...

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Principais autores:	Karène Urgin, Mouhamad Jida, Katharina Ehrhardt, Tobias Müller, Michael Lanzer, Louis Maes, Mourad Elhabiri, Elisabeth Davioud-Charvet
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2017-01-01
coleção:	Molecules
Assuntos:	antimalarial N-arylalkylamines atovaquone biaryls menadione 1,4-naphthoquinone plasmodione redox-cycling reductive amination Suzuki-Miyaura coupling
Acesso em linha:	http://www.mdpi.com/1420-3049/22/1/161
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