Malignancy and gene therapy in hemophilia
Despite the misconception that adeno-associated virus (AAV) gene therapy vectors are nonintegrating, they can integrate into the host genome at a low but nonnegligible frequency, posing a theoretical risk of tumorigenesis. While AAV integration can trigger hepatocellular carcinoma in mice, no such a...
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| Auteur principal: | |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Elsevier
2026-01-01
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| Collection: | Research and Practice in Thrombosis and Haemostasis |
| Sujets: | |
| Accès en ligne: | http://www.sciencedirect.com/science/article/pii/S2475037925006077 |
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