PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors
Summary: CDC7 kinase is crucial for DNA replication initiation and fork processing. CDC7 inhibition mildly activates the ATR pathway, which further limits origin firing; however, to date the relationship between CDC7 and ATR remains controversial. We show that CDC7 and ATR inhibitors are either syne...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Elsevier
2023-06-01
|
| Colección: | iScience |
| Materias: | |
| Acceso en línea: | http://www.sciencedirect.com/science/article/pii/S2589004223010283 |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|