Tumor-associated high endothelial venules are associated with enhanced lymphocyte infiltration and favorable prognosis in resected hepatocellular carcinoma

Abstract Background Tumor-infiltrating lymphocytes (TILs) are essential to effective immunotherapy for hepatocellular carcinoma (HCC). Among factors regulating TILs, tumor-associated high endothelial venules (TA–HEVs) have been identified in various cancers and may contribute to TIL recruitment. Thi...

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Autori principali:	Shu Aoyama, Takehiro Noda, Hirofumi Akita, Yosuke Mukai, Kazuki Sasaki, Shinichiro Hasegawa, Daisaku Yamada, Yoshito Tomimaru, Tadafumi Asaoka, Hidenori Takahashi, Shogo Kobayashi, Junzo Shimizu, Azumi Ueyama, Takuro Saito, Kansuke Kido, Eiichi Morii, Hisashi Wada, Yuichiro Doki, Hidetoshi Eguchi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer 2025-12-01
Serie:	Cancer Immunology, Immunotherapy
Soggetti:	Primary liver tumor Tertiary lymphoid structure Tumor-infiltrating lymphocyte Tumor microenvironment Immune checkpoint molecules
Accesso online:	https://doi.org/10.1007/s00262-025-04265-z
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