Quantification of intrinsic subtype ambiguity in Luminal A breast cancer and its relationship to clinical outcomes

Abstract Background PAM50 gene profiling assigns each cancer to a single intrinsic subtype. However, individual cancers vary in their adherence to a prototype, and due to bulk tissue sampling, some may exhibit expression patterns that indicate intra-tumor admixture of multiple subtypes. Our objectiv...

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Autori principali:	Neeraj Kumar, Dan Zhao, Dulal Bhaumik, Amit Sethi, Peter H. Gann
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2019-03-01
Serie:	BMC Cancer
Soggetti:	Intrinsic subtype Intratumor heterogeneity PAM50 Luminal a
Accesso online:	http://link.springer.com/article/10.1186/s12885-019-5392-z
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