Insights Into the Role of CSF1R in the Central Nervous System and Neurological Disorders

The colony-stimulating factor 1 receptor (CSF1R) is a key tyrosine kinase transmembrane receptor modulating microglial homeostasis, neurogenesis, and neuronal survival in the central nervous system (CNS). CSF1R, which can be proteolytically cleaved into a soluble ectodomain and an intracellular prot...

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Hlavní autoři:	Banglian Hu, Shengshun Duan, Ziwei Wang, Xin Li, Yuhang Zhou, Xian Zhang, Yun-Wu Zhang, Huaxi Xu, Honghua Zheng
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-11-01
Edice:	Frontiers in Aging Neuroscience
Témata:	CSF1R microglia microglial maintenance neurogenesis CSF1R cleavage CSF1R mutations
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fnagi.2021.789834/full
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