Putative glymphatic dysfunction links extracellular fluid dysregulation to white matter degeneration and clinical impairment in amyotrophic lateral sclerosis

Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degeneration and prominent extra-motor involvement. Impaired clearance of neurotoxic proteins has led to increasing interest in the brain glymphatic system; however...

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Asıl Yazarlar:	Xin Jin, Yan Fu, Ting Qiu, Jianyu Li, Huixiong Zhang, Yifan Chen, Kewei Chen, Yuanchao Zhang, Junling Wang, Xiaoping Yi, Lena Palaniyappan, B. Blair Braden
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	BMC 2026-05-01
Seri Bilgileri:	BMC Medicine
Konular:	ALS Glymphatic system White matter integrity DTI-ALPS Free-water fraction
Online Erişim:	https://doi.org/10.1186/s12916-026-04948-z
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