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Phosphorylated EGFR expression may predict outcome of EGFR-TKIs therapy for the advanced NSCLC patients with wild-type EGFR

<p>Abstract</p> <p>Background</p> <p>EGFR mutation is a strong predictive factor of EGFR-TKIs therapy. However, at least 10% of patients with EGFR wild-type are responsive to TKIs, suggesting that other determinants of outcome besides EGFR mutation might exist. We hypothesized that activation of pho...

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Principais autores: Wang Fen, Wang Shuhang, Wang Zhijie, Duan Jianchun, An Tongtong, Zhao Jun, Bai Hua, Wang Jie
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2012-08-01
Serier:Journal of Experimental & Clinical Cancer Research
Fag:
EGFR phosphorylation
EGFR mutation
Non-small cell lung cancer
Online adgang:http://www.jeccr.com/content/31/1/65
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