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Exploring environmental modifiers of LRRK2-associated Parkinson’s disease penetrance: An exposomics and metagenomics pilot study on household dust

Pathogenic variants in the Leucine-rich repeat kinase 2 (LRRK2) gene are a primary monogenic cause of Parkinson’s disease (PD). However, the likelihood of developing PD with inherited LRRK2 pathogenic variants differs (a phenomenon known as “reduced penetrance”), with factors including age and geogr...

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Principais autores: Begoña Talavera Andújar, Sandro L. Pereira, Susheel Bhanu Busi, Tatiana Usnich, Max Borsche, Sibel Ertan, Peter Bauer, Arndt Rolfs, Soraya Hezzaz, Jenny Ghelfi, Norbert Brüggemann, Paul Antony, Paul Wilmes, Christine Klein, Anne Grünewald, Emma L. Schymanski
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-12-01
Serier:Environment International
Fag:
Indoor environment
Exposomics
Metagenomics
Parkinson’s disease
Leucine-rich repeat kinase 2 (LRRK2)
Bisphenol S
Online adgang:http://www.sciencedirect.com/science/article/pii/S0160412024007372
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