Δ-Tetrahydrocannabinol Increases Dopamine D1-D2 Receptor Heteromer and Elicits Phenotypic Reprogramming in Adult Primate Striatal Neurons

Summary: Long-term cannabis users manifest deficits in dopaminergic functions, reflecting Δ9-tetrahydrocannabinol (THC)-induced neuroadaptive dysfunctional dopamine signaling, similar to those observed upon dopamine D1-D2 heteromer activation. The molecular mechanisms remain largely unknown. We show...

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Autori principali:	Ahmed Hasbi, Bertha K. Madras, Jack Bergman, Stephen Kohut, Zhicheng Lin, Sarah L. Withey, Susan R. George
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2020-01-01
Serie:	iScience
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2589004219305401
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