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Drug prioritization identifies panobinostat as a tailored treatment element for patients with metastatic hepatoblastoma

Abstract Background Patients with metastatic hepatoblastoma are treated with severely toxic first-line chemotherapies in combination with surgery. Yet, inadequate response of lung metastases to neo-adjuvant chemotherapy still compromises patient outcomes making new treatment strategies, tailored to...

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Principais autores: Salih Demir, Alina Hotes, Tanja Schmid, Stefano Cairo, Emilie Indersie, Claudio Pisano, Eiso Hiyama, Tomoro Hishiki, Christian Vokuhl, Sophie Branchereau, Penelope Brock, Irene Schmid, József Zsiros, Roland Kappler
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-11-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
Hepatoblastoma
Metastasis
Panobinostat
Therapy
MYC
Acesso em linha:https://doi.org/10.1186/s13046-024-03221-6
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