Combined in Vitro and in Silico Studies for the Anticholinesterase Activity and Pharmacokinetics of Coumarinyl Thiazoles and Oxadiazoles

In a continuation of our previous work for the exploration of novel enzyme inhibitors, two new coumarin-thiazole 6(a–o) and coumarin-oxadiazole 11(a–h) hybrids have been designed and synthesized. All the compounds were characterized by 1H- and 13C-NMR spectroscopy and elemental analysis. New hybrid...

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Hlavní autoři:	Aliya Ibrar, Ajmal Khan, Majid Ali, Rizwana Sarwar, Saifullah Mehsud, Umar Farooq, Syed M. A. Halimi, Imtiaz Khan, Ahmed Al-Harrasi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2018-03-01
Edice:	Frontiers in Chemistry
Témata:	coumarin thiazoles coumarin oxadiazoles cholinesterase inhibition molecular docking MOE score
On-line přístup:	http://journal.frontiersin.org/article/10.3389/fchem.2018.00061/full
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