Enhanced supply of acetyl-CoA by exogenous pantothenate kinase promotes synthesis of poly(3-hydroxybutyrate)

Abstract Background Coenzyme A (CoA) is a carrier of acyl groups. This cofactor is synthesized from pantothenic acid in five steps. The phosphorylation of pantothenate is catalyzed by pantothenate kinase (CoaA), which is a key step in the CoA biosynthetic pathway. To determine whether the enhancemen...

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Autori principali:	Hirotaka Kudo, Sho Ono, Kenta Abe, Mami Matsuda, Tomohisa Hasunuma, Tomoyasu Nishizawa, Munehiko Asayama, Hirofumi Nishihara, Shigeru Chohnan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-04-01
Serie:	Microbial Cell Factories
Soggetti:	Coenzyme A Acetyl-CoA Pantothenate kinase Poly(3-hydroxybutyrate) Escherichia coli Pantothenic acid
Accesso online:	https://doi.org/10.1186/s12934-023-02083-5
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