Synthesis and SAR Study of Novel Peptide Aldehydes as Inhibitors of 20S Proteasome

Based on the analysis of the crystal structure of MG101 (1) and 20S proteasomes, a new series of peptide aldehyde derivatives were designed and synthesized. Their ability to inhibit 20S proteasome was assayed. Among them, Cbz-Glu(OtBu)-Phe-Leucinal (3c), Cbz-Glu(OtBu)-Leu-Leucinal (3d), and Boc-Ser(...

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Autores principales:	Lihe Zhang, Liangren Zhang, Jingrong Cui, Zhenjun Yang, Yuan Fang, Bo Xu, Yuheng Ma
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2011-09-01
Colección:	Molecules
Materias:	20S proteasome inhibitor peptide aldehydes synthesis structure-activity relationship
Acceso en línea:	http://www.mdpi.com/1420-3049/16/9/7551/
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