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Phase 1/2 study of H3B-6545 in women with locally advanced/metastatic estrogen receptor-positive, HER2-negative breast cancer

Abstract Background Although endocrine therapies, alone or in combination with CDK4/6 inhibitors, have led to notable improvements in the treatment of estrogen receptor-positive (ER+) breast cancer, progression is inevitable for most patients. We report dose escalation and expansion data from a tria...

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Huvudupphov: Erika Hamilton, Timothy Pluard, Judy S. Wang, Aki Morikawa, Stephen Johnston, E. Claire Dees, Christos Vaklavas, Anne Armstrong, Pamela Munster, Nisha Unni, Gail S. Wright, Fadi Kayali, Tingting Song, Yuanxin Rong, Kohei Yamaguchi, Dejan Juric
Materialtyp: Artigo
Språk:Inglês
Utgiven: BMC 2025-08-01
Serie:Breast Cancer Research
Ämnen:
H3B-6545
Breast cancer
Endocrine therapy
HER2-negative
Estrogen receptor-positive
Länkar:https://doi.org/10.1186/s13058-025-02069-8
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