A new FRDA mouse model [Fxnnull:YG8s(GAA) > 800] with more than 800 GAA repeats
IntroductionFriedreich’s ataxia (FRDA) is an inherited recessive neurodegenerative disorder caused by a homozygous guanine-adenine-adenine (GAA) repeat expansion within intron 1 of the FXN gene, which encodes the essential mitochondrial protein frataxin. There is still no effective therapy for FRDA,...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Neuroscience |
| Assuntos: | |
| Acceso en liña: | https://www.frontiersin.org/articles/10.3389/fnins.2023.930422/full |
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