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RAF inhibitor re-challenge therapy in BRAF-aberrant pan-cancers: the RE-RAFFLE study

Abstract Previous studies have shown the clinical benefit of rechallenging the RAF pathway in melanoma patients previously treated with BRAF inhibitors. 44 patients with multiple tumors harboring RAF alterations were rechallenged with a second RAF inhibitor, either as monotherapy or in combination w...

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Furkejuvvon:
Váldodahkkit: Blessie Elizabeth Nelson, Jason Roszik, Jibran Ahmed, Carmelia Maria Noia Barretto, Mirella Nardo, Erick Campbell, Amber M Johnson, Sarina A. Piha-Paul, Isabella C. Glitza Oliva, Shiao-Pei Weathers, Maria Cabanillas, Milind Javle, Funda Meric-Bernstam, Vivek Subbiah
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: BMC 2024-03-01
Ráidu:Molecular Cancer
Fáttát:
Rechallenge
RAF pathway
BRAF inhibitors
BRAF-altered solid tumors
Liŋkkat:https://doi.org/10.1186/s12943-024-01982-4
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