T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor.
Hedgehog signaling is primarily transduced by two transcription factors: Gli2, which mainly acts as a full-length activator, and Gli3, which tends to be proteolytically processed from a full-length form (Gli3FL) to an N-terminal repressor (Gli3REP). Recent studies using a Sufu knockout mouse have in...
Tallennettuna:
| Päätekijät: | , , , , , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Public Library of Science (PLoS)
2015-01-01
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| Sarja: | PLoS ONE |
| Linkit: | http://europepmc.org/articles/PMC4356511?pdf=render |
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