Hypoxia-inducible factor-1α regulates chemotactic migration of pancreatic ductal adenocarcinoma cells through directly transactivating the CX3CR1 gene.

CX3CR1 is an important chemokine receptor and regulates the chemotactic migration of pancreatic ductal adenocarcinoma (PDAC) cells. Up to now, its regulatory mechanism remains largely undefined. Here, we report that hypoxia upregulates the expression of CX3CR1 in pancreatic cancer cells. When hypoxi...

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Ngā kaituhi matua:	Tiansuo Zhao, Song Gao, Xiuchao Wang, Jingcheng Liu, Yitao Duan, Zhanna Yuan, Jun Sheng, Shasha Li, Feng Wang, Ming Yu, He Ren, Jihui Hao
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Public Library of Science (PLoS) 2012-01-01
Rangatū:	PLoS ONE
Urunga tuihono:	http://europepmc.org/articles/PMC3428361?pdf=render
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!