Diabetes-Induced Amplification of Nociceptive DRG Neuron Output by Upregulation of Somatic T-Type Ca²⁺ Channels

The development of pain symptoms in peripheral diabetic neuropathy (PDN) is associated with the upregulation of T-type Ca²⁺ channels (T-channels) in the soma of nociceptive DRG neurons. Moreover, a block of these channels in DRG neurons effectively reversed mechanical and thermal hyperalg...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Arsentii Ivasiuk, Maksym Matvieienko, Nikolai I. Kononenko, Dmytro E. Duzhyy, Sergiy M. Korogod, Nana Voitenko, Pavel Belan
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-08-01
Schriftenreihe:	Biomolecules
Schlagworte:	calcium current diabetic painful neuropathy action potential spinal cord nociception temperature dependence
Online-Zugang:	https://www.mdpi.com/2218-273X/13/9/1320
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