TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin deposition

Abstract In pulmonary fibrosis lung tissue is thickened and scarred, and the lungs become progressively stiffer and smaller, leading to low levels of blood oxygen and shortness of breath. Lung fibrosis is not curable and life expectancy is reduced. Fibrosis is characterized by an increased accumulat...

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主要な著者:	Eva-Maria Weiden, Zala Serianz, Yvonne Klingl, Simone Jörs, Dawid Jaślan, Marco Keller, Sandra Prat Castro, Mane Mkhitaryan, Aicha Jeridi, Daria Briukhovetska, Barbara Spix, Anna Scotto Rosato, Ahmed Agami, Herbert B Schiller, Suhasini Rajan, Johann Schredelseker, Giorgio Fois, Manfred Frick, Sebastian Kobold, Margarethe Klein, Fabian Geisler, Jorge Garcia-Fortanet, Leon O Murphy, Franz Bracher, Christian Wahl-Schott, Thomas Gudermann, Alexander Dietrich, Martin Biel, Ali Önder Yildirim, Christian Grimm
フォーマット:	Artigo
言語:	Inglês
出版事項:	Springer Nature 2026-02-01
シリーズ:	The EMBO Journal
主題:	TRPML TRPML1 TRPML3 Mcoln1 Pulmonary Fibrosis
オンライン･アクセス:	https://doi.org/10.1038/s44318-026-00712-4
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