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Human pancreatic tumour organoid‐derived factors enhance myogenic differentiation

Abstract Background Most patients with pancreatic cancer develop cachexia, which is characterized by progressive muscle loss. The mechanisms underlying muscle loss in cancer cachexia remain elusive. Pancreatic tumour organoids are 3D cell culture models that retain key characteristics of the parent...

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Principais autores: Rianne D.W. Vaes, David P.J. vanDijk, Elham Aïda Farshadi, Steven W.M. Olde Damink, Sander S. Rensen, Ramon C. Langen
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2022-04-01
Serier:Journal of Cachexia, Sarcopenia and Muscle
Fag:
Cachexia
Skeletal muscle atrophy
Organoids
E3 ubiquitin ligases
Myogenesis
Online adgang:https://doi.org/10.1002/jcsm.12917
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