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Transfer of SARS-CoV-2 nucleocapsid protein to uninfected epithelial cells induces antibody-mediated complement deposition

Summary: SARS-CoV-2 infection triggers a strong antibody response toward nucleocapsid protein (NP), suggesting its extracellular presence beyond intravirion RNA binding. Our co-culture experiments show NP decorates infected and proximal uninfected cell surfaces. We propose a mechanism whereby extrac...

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I tiakina i:
Ngā kaituhi matua: Jamal Fahoum, Maria Billan, Julia K. Varga, Dan Padawer, Yelena Britan-Rosich, Maya Elgrably-Weiss, Pallabi Basu, Miri Stolovich-Rain, Leah Baraz, Einav Cohen-Kfir, Sujata Kumari, Esther Oiknine-Djian, Manoj Kumar, Orly Zelig, Guy Mayer, Michail N. Isupov, Dana G. Wolf, Shoshy Altuvia, Reuven Wiener, Ora Schueler-Furman, Alexander Rouvinski
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Elsevier 2025-05-01
Rangatū:Cell Reports
Ngā marau:
CP: Immunology
Urunga tuihono:http://www.sciencedirect.com/science/article/pii/S2211124725002839
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