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Neuronal tissue collection from intra-cranial instruments used in deep brain stimulation surgery for Parkinson’s disease with implications for study of alpha-synuclein

Abstract Alpha-synuclein (αSyn) forms pathologic aggregates in Parkinson’s disease (PD) and is implicated in mechanisms underlying neurodegeneration. While pathologic αSyn has been extensively studied, there is currently no method to evaluate αSyn within the brains of living patients. Patients with...

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Kaydedildi:
Asıl Yazarlar: Zachary A. Sorrentino, Joshua Riklan, Grace M. Lloyd, Brandon P. Lucke-Wold, David Mampre, Stephan Quintin, Rasheedat Zakare-Fagbamila, Megan Still, Vyshak Chandra, Kelly D. Foote, Benoit I. Giasson, Justin D. Hilliard
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Portfolio 2024-09-01
Seri Bilgileri:Scientific Reports
Konular:
Parkinson’s disease
Alpha-synuclein
Essential tremor
Deep brain stimulation
Neurodegeneration
Online Erişim:https://doi.org/10.1038/s41598-024-72542-5
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