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Hepatoprotective action of Sonchus oleraceus against paracetamol-induced toxicity via Nrf2/KEAP-1/HO-1 pathway in relation to its metabolite fingerprint and in silico studies.

<h4>Background</h4>Paracetamol overdose causes severe hepatotoxicity. Sonchus oleraceus is traditionally used to treat liver disorders, but its potential against paracetamol-induced liver injury is unexplored. This work aimed to investigate the protective mechanisms of an S. oleraceus extract (SOEtO...

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Principais autores: Mohamed F Abdelhameed, Marawan A El-Baset, Amira R Khattab, Rehab F Taher, Mohamed A El-Saied, Asmaa S Abd Elkarim, Ahmed F Essa, Ahmed A El-Rashedy, Mohamed A Farag, Hiroshi Imagawa, Abdelsamed I Elshamy, Ahmed M Abd-ElGawad
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2025-01-01
Serier:PLoS ONE
Online adgang:https://doi.org/10.1371/journal.pone.0325782
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