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Inhibiting triggering receptor expressed on myeloid cells 1 signaling to ameliorate skin fibrosis

Systemic sclerosis (SSc) is characterized by immune system failure, vascular insult, autoimmunity, and tissue fibrosis. TGF-β is a crucial mediator of persistent myofibroblast activation and aberrant extracellular matrix production in SSc. The factors responsible for this are unknown. By amplifying...

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Principais autores: Swarna Bale, Priyanka Verma, Bharath Yalavarthi, Matija Bajželj, Syed A.M. Hasan, Jenna N. Silverman, Katherine Broderick, Kris A. Shah, Timothy Hamill, Dinesh Khanna, Alexander B. Sigalov, Swati Bhattacharyya, John Varga
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical investigation 2024-12-01
coleção:JCI Insight
Assuntos:
Autoimmunity
Infectious disease
Acesso em linha:https://doi.org/10.1172/jci.insight.176319
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