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Phosphatidylcholine with C26:0 moiety, a precursor of a diagnostic marker for X-ALD, is synthesized by LPLAT10/LPEAT2

X-linked adrenoleukodystrophy (X-ALD) is a congenital metabolic disorder characterized mainly by inflammatory demyelination and adrenal insufficiency. Newborn screening using hexacosanoyl lysophosphatidylcholine (C26:0-LPC) in dried blood spots as a diagnostic marker can successfully identify potent...

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Main Authors: Kotaro Hama, Yuko Fujiwara, Koko Imai, Yoshio Kusakabe, Yasuhiro Hayashi, Shigeo Takashima, Shohei Azuma, Masaru Kondo, Atsushi Yamashita, Ryo Takita, Nobuyuki Shimozawa, Kazuaki Yokoyama
Format: Artigo
Language:Inglês
Published: Elsevier 2026-02-01
Series:Journal of Lipid Research
Subjects:
C26:0-lysophosphatidylcholine
fatty acid/transport
glycerophospholipids
lysophospholipid acyltransferase
lipolysis and fatty acid metabolism
newborn screening
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227525002366
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