Rewiring melanoma cell fate: TRPM8 modulators trigger apoptosis and boost NK cell cytotoxicity

Abstract Metastatic melanoma is an aggressive malignancy with limited long-term treatment success due to therapeutic resistance and immune evasion. The transient receptor potential melastatin 8 (TRPM8) ion channel is overexpressed in melanoma but its role as therapeutic target remains unexplored. We...

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Bibliografski detalji

Glavni autori:	Carmela Sorrentino, Carmine Lauretta, Rosa D’Angiolo, Simona Musella, Pia Giovannelli, Alessia Bertamino, Carmine Ostacolo, Isabel Gomez Monterrey, Antimo Migliaccio, Gabriella Castoria, Marzia Di Donato
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Publishing Group 2026-02-01
Serija:	Cell Death and Disease
Online pristup:	https://doi.org/10.1038/s41419-026-08469-8
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