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A Phase II Randomized Clinical Trial and Mechanistic Studies Using Improved Probiotics to Prevent Oral Mucositis Induced by Concurrent Radiotherapy and Chemotherapy in Nasopharyngeal Carcinoma

Earlier evidence has proven that probiotic supplements can reduce concurrent chemoradiotherapy (CCRT)-induced oral mucositis (OM) in nasopharyngeal cancer (NPC). The incidence of severe OM (grade 3 or higher) was the primary endpoint in this study. We first enrolled 85 patients with locally advanced...

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Principais autores: Chaofei Xia, Chunling Jiang, Wenyu Li, Jing Wei, Hu Hong, Jingao Li, Liu Feng, Hong Wei, Hongbo Xin, Tingtao Chen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-03-01
Serier:Frontiers in Immunology
Fag:
probiotics
oral mucositis
intestinal microbiota
nasopharyngeal cancer
radiotherapy and chemotherapy
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2021.618150/full
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