The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins

As a first-line vertebrate immune defense, the polymeric immunoglobulin receptor (pIgR) transports polymeric IgA and IgM across epithelia to mucosal secretions, where the cleaved ectodomain (secretory component; SC) becomes a component of secretory antibodies, or when unliganded, binds and excludes...

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Autori principali:	Beth M Stadtmueller, Kathryn E Huey-Tubman, Carlos J López, Zhongyu Yang, Wayne L Hubbell, Pamela J Bjorkman
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	eLife Sciences Publications Ltd 2016-03-01
Serie:	eLife
Soggetti:	polymeric ig receptor (pIgR) secretory component (SC) secretory igA/igM crystal structures double electron-electron resonance surface plasmon resonance
Accesso online:	https://elifesciences.org/articles/10640
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