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Beyond bisphosphonates: radiolabeled phosphopeptides for bone targeting

Abstract Background The efficacy of current bone-targeting agents, notably bisphosphonates, in the treatment of bone metastases remains limited by their systemic toxicity and excessively long half-life. This study aims to develop bone-targeting agents inspired by osteotropic peptides involved in the...

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Principais autores: Mazen Jamous, Barbara Roether, Eric Mühlberg, Christian Kleist, Armin Kübelbeck, Uwe Haberkorn, Walter Mier
Format: Artigo
Sprog:Inglês
Udgivet: SpringerOpen 2026-04-01
Serier:EJNMMI Research
Fag:
Bone targeting
Bisphosphonates
Hydroxyapatite
Phosphopeptides
Online adgang:https://doi.org/10.1186/s13550-026-01437-5
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