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Astrocyte-specific deletion of LRRC8A causes neurological dysfunction but not chronic white matter edema

Volume-regulated anion channels (VRACs) are central to cell volume homeostasis. They mediate swelling-induced efflux of chloride and organic osmolytes to drive regulatory volume decrease. In the brain, VRACs have been proposed to play a key role in astrocytic volume regulation. Genetic defects in as...

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Hlavní autoři: Sven Kerst, Leoni Hoogterp, Marjolein Breur, Gemma M. van Rooijen-van Leeuwen, Marianna Bugiani, Rajan Sah, Huibert D. Mansvelder, Marjo S. van der Knaap, Rogier Min
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2026-03-01
Edice:Neurobiology of Disease
Témata:
LRRC8A
VRAC
Astrocyte
Volume regulation
White matter edema
Leukodystrophy
On-line přístup:http://www.sciencedirect.com/science/article/pii/S0969996126000574
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