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Competition between VanU(G) repressor and VanR(G) activator leads to rheostatic control of vanG vancomycin resistance operon expression.

Enterococcus faecalis BM4518 is resistant to vancomycin by synthesis of peptidoglycan precursors ending in D-alanyl-D-serine. In the chromosomal vanG locus, transcription of the resistance genes from the PYG resistance promoter is inducible and, upstream from these genes, there is an unusual three-c...

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Principais autores: Florence Depardieu, Vincent Mejean, Patrice Courvalin
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science (PLoS) 2015-04-01
Series:PLoS Genetics
Acceso en liña:http://europepmc.org/articles/PMC4405338?pdf=render
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