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Biological Effects of BET Inhibition by OTX015 (MK-8628) and JQ1 in NPM1-Mutated (NPM1c) Acute Myeloid Leukemia (AML)

BET inhibitors (BETi) including OTX015 (MK-8628) and JQ1 demonstrated antileukemic activity including <i>NPM1c</i> AML cells. Nevertheless, the biological consequences of BETi in <i>NPM1c</i> AML were not fully investigated. Even if of better prognosis AML patients with <i>NPM1c</i> may relapse and...

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Principais autores: Hanane Djamai, Jeannig Berrou, Mélanie Dupont, Marie-Magdelaine Coudé, Marc Delord, Emmanuelle Clappier, Alice Marceau-Renaut, Anna Kaci, Emmanuel Raffoux, Raphaël Itzykson, Caroline Berthier, Hsin-Chieh Wu, Rita Hleihel, Ali Bazarbachi, Hugues de Thé, André Baruchel, Claude Gardin, Hervé Dombret, Thorsten Braun
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-11-01
Serier:Biomedicines
Fag:
BET inhibitors
OTX015 (MK-8628)
JQ1
ATRA
ATO
<i>HOX</i> genes
Online adgang:https://www.mdpi.com/2227-9059/9/11/1704
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