ATP-binding cassette transporters mediate differential biosynthesis of glycosphingolipid species

The cytosolic-oriented glucosylceramide (GlcCer) synthase is enigmatic, requiring nascent GlcCer translocation to the luminal Golgi membrane to access glycosphingolipid (GSL) anabolic glycosyltransferases. The mechanism by which GlcCer is flipped remains unclear. To investigate the role of GlcCer-bi...

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Detalhes bibliográficos

Principais autores:	Monique Budani, Christiane Auray-Blais, Clifford Lingwood
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2021-01-01
coleção:	Journal of Lipid Research
Assuntos:	ABC transporter glucosylceramide flippase glycosphingolipid photoprobes metabolic labeling LacCer
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227521001103
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