Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits
It has been proposed that deregulation of neuronal glycogen synthase kinase 3 (GSK3) activity may be a key feature in Alzheimer disease pathogenesis. We have previously generated transgenic mice that overexpress GSK3β in forebrain regions including dentate gyrus (DG), a region involved in learning a...
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| Главные авторы: | , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Elsevier
2010-03-01
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| Серии: | Neurobiology of Disease |
| Предметы: | |
| Online-ссылка: | http://www.sciencedirect.com/science/article/pii/S0969996109003398 |
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