Systemic Pharmacological Smoothened Inhibition Reduces Lung T-Cell Infiltration and Ameliorates Th2 Inflammation in a Mouse Model of Allergic Airway Disease

Allergic asthma is a common inflammatory airway disease in which Th2 immune response and inflammation are thought to be triggered by inhalation of environmental allergens. Many studies using mouse models and human tissues and genome-wide association have indicated that Sonic Hedgehog (Shh) and the H...

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Hlavní autoři:	Diana C. Yánez, Eleftheria Papaioannou, Mira M. Chawda, Jasmine Rowell, Susan Ross, Ching-In Lau, Tessa Crompton
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-09-01
Edice:	Frontiers in Immunology
Témata:	smoothened (SMO) airway inflammation Th2 Sonic Hedgehog (Shh) CD4 T-cell
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.737245/full
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