Glutamine-Glutamate Cycle Flux Is Similar in Cultured Astrocytes and Brain and Both Glutamate Production and Oxidation Are Mainly Catalyzed by Aspartate Aminotransferase

The glutamine-glutamate cycle provides neurons with astrocyte-generated glutamate/γ-aminobutyric acid (GABA) and oxidizes glutamate in astrocytes, and it returns released transmitter glutamate/GABA to neurons after astrocytic uptake. This review deals primarily with the glutamate/GABA generation/oxi...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Leif Hertz, Douglas L Rothman
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2017-02-01
Schriftenreihe:	Biology
Schlagworte:	aspartate aminotransferase astrocyte culture brain metabolism glutamate-glutamine cycle glutamate dehydrogenase glutamate oxidation glutamine synthetase malate-aspartate shuttle metabolic compartmentation nitrogen balance
Online-Zugang:	http://www.mdpi.com/2079-7737/6/1/17
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