CYP1A2 mRNA Expression Rather than Genetic Variants Indicate Hepatic CYP1A2 Activity

CYP1A2, one of the most abundant hepatic cytochrome P450 enzymes, is involved in metabolism of several drugs and carcinogenic compounds. Data on the significance of <i>CYP1A2</i> genetic polymorphisms in enzyme activity are highly inconsistent; therefore, the impact of <i>CYP1A2</i> genetic variants...

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Hlavní autoři:	Ferenc Fekete, Katalin Mangó, Annamária Minus, Katalin Tóth, Katalin Monostory
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-02-01
Edice:	Pharmaceutics
Témata:	CYP1A2 phenacetin <i>O</i>-dealkylation activity CYP1A2 expression <i>CYP1A2</i> genetic polymorphisms non-genetic factors smoking
On-line přístup:	https://www.mdpi.com/1999-4923/14/3/532
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