Proprotein convertase subtilisin/kexin type 9 deficiency in extrahepatic tissues: emerging considerations

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily secreted by hepatocytes. PCSK9 is critical in liver low-density lipoprotein receptors (LDLRs) metabolism. In addition to its hepatocellular presence, PCSK9 has also been detected in cardiac, cerebral, islet, renal, adipose, and other...

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Autors principals:	Fengyuan Lu, En Li, Xiaoyu Yang
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2024-07-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	PCSK9 PCSK9 deficiency PCSK9 inhibition PCSK9 monoclonal antibody low-density lipoprotein receptors
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fphar.2024.1413123/full
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