Therapeutic Response to Non-genotoxic Activation of p53 by Nutlin3a Is Driven by PUMA-Mediated Apoptosis in Lymphoma Cells

Nutlin3a is a small-molecule antagonist of MDM2 that promotes non-genotoxic activation of p53 through p53 protein stabilization and transactivation of p53 target genes. Nutlin3a is the forerunner of a class of cancer therapeutics that have reached clinical trials. Using transgenic and gene-targeted...

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Detalhes bibliográficos

Principais autores:	Liz J. Valente, Brandon J. Aubrey, Marco J. Herold, Gemma L. Kelly, Lina Happo, Clare L. Scott, Andrea Newbold, Ricky W. Johnstone, David C.S. Huang, Lyubomir T. Vassilev, Andreas Strasser
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2016-03-01
coleção:	Cell Reports
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124716300377
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