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A Micro-Quantitative and FFPE-Compatible Workflow for Immunohistochemistry-Guided Spatial Proteomic Analysis of Cellular Subpopulations Within the Tumor Microenvironment

Understanding the spatial proteomic landscape of human tumors is essential for dissecting cellular heterogeneity and microenvironmental interactions in cancer biology. Traditional bulk proteomic approaches, however, obscure spatial information and average out signals from distinct cell populations....

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Principais autores: Junya Peng, Lu Ping, Ruikang Dun, Lulu Liu, Yihong Shi, Ruizhe He, Qing Zhong, Yang Chen, Wenmin Tian, Yupei Zhao
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-06-01
Serier:Bioengineering
Fag:
laser microdissection
immunohistochemistry
FFPE tissue
tumor microenvironment
Online adgang:https://www.mdpi.com/2306-5354/13/6/678
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